Sunday, June 3, 2012

Craig Venter's Biotechnology Dreams

NYT, via Ritholtz:
The appeal of biological machinery is manifold. For one thing, because organisms reproduce, they can generate not only their target product but also more factories to do the same. Then too, microbes use novel fuel. Chances are, unless you’ve slipped off the grid, virtually every machine you own, from your iPhone to your toaster oven, depends on burning fossil fuels to work. Even if you have slipped off the grid, manufacturing those devices required massive carbon emissions. This is not necessarily the case for biomachinery. A custom organism could produce the same plastic or metal as an industrial plant while feeding on the compounds in pollution or the energy of the sun.
Then there is the matter of yield. Over the last 60 years, agricultural production has boomed in large part through plant modification, chemical additives and irrigation. But as the world population continues to soar, adding nearly a billion people over the past decade, major aquifers are giving out, and agriculture may not be able to keep pace with the world’s needs. If a strain of algae could secrete high yields of protein, using less land and water than traditional crops, it may represent the best hope to feed a booming planet.
Finally, the rise of biomachinery could usher in an era of spot production. “Biology is the ultimate distributed manufacturing platform,” Drew Endy, an assistant professor at Stanford University, told me recently. Endy is trained as an engineer but has become a leading proponent of synthetic biology. He sketched a picture of what “distributed manufacturing” by microbes might look like: say a perfume company could design a bacterium to produce an appealing aroma; “rather than running this in a large-scale fermenter, they would upload the DNA sequences onto the future equivalent of iTunes,” he said. “People all over the world could then pay a fee to download the information.” Then, Endy explained, customers could simply synthesize the bugs at home and grow them on their skin. “They could transform epidermal ecosystems to have living production of scents and fragrances,” he said. “Living perfume!”
Not surprisingly, I'm in the skeptical camp.  But I have to say that he has some really interesting ideas.

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